- Lee PC, Jung IH, Thussu S, Patel V, Wagoner R, Burks KH, Amrute J, Elenbaas JS, Kang CJ, Young EP, Scherer PE, Stitziel NO. Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease. iScience. 2024 May;27(7):110104.
- Jung IH, Stitziel NO. Integrin a9ß1 deficiency does not impact the development of atherosclerosis in mice. Heliyon. 2024 Feb 9; (10):e25760.
- Elenbaas JS, Jung HJ, Coler-Reilly A, Lee PC, Alisio A, Stitziel NO. The emerging Janus face of SVEP1 in development and disease. Trends Mol Med. 2023 Nov;29(11):939-950.
- Kendall H. Burks, Debapriya Basu, Ira J. Goldberg, Nathan O. Stitziel. Angiopoietin-like 3: An important protein in regulating lipoprotein levels. Best Pract Res Clin Endocrinol Metab. 2023 May;37(3):101688.
- Samantha K. Barrick, Ankit Garg, Lina Greenberg, Shanshan Zhang, Chieh Yu Lin, Nathan O. Stitziel, Michael Greenberg. Functional Assays Reveal the Pathogenic Mechanism of a De Novo Tropomyosin Variant Identified In Patient With Dilated Cardiomyopathy. J Mol Cell Cardiol. 2023 Mar;176:58-67.
- Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Aliso, Jorge Di Paola, Nathan O. Stitziel. SVEP1 is an Endogenous Ligand for the Orphan Receptor PEAR1. Nat Commun. 2023 Feb 15;14(1):850.
- SVEP1 is a Human Coronary Artery Disease Locus that Promotes Atherosclerosis. Sci Transl Med. 2021 Mar 24;13(586):eabe0357.
ONLINE COVER Proliferation in Plaques. This immunofluorescence image shows a marker of proliferation (minichromosome maintenance protein–2, cyan) and smooth muscle α-actin (red) in a mouse aorta; nuclei are counterstained blue. Jung et al. studied how the extracellular matrix protein sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) contributes to atherosclerosis. They observed less proliferation of vascular smooth muscle cells, reduced inflammation, and smaller plaques in mice lacking transcription of the Svep1 gene in vascular smooth muscle cells. Human plasma samples showed that high SVEP1 concentration was associated with increased risk of coronary artery disease. These results suggest that targeting SVEP1 could be therapeutic for atherosclerosis. [CREDIT: JUNG ET AL./SCIENCE TRANSLATIONAL MEDICINE]
- Emerging Targets for Cardiovascular Disease Prevention in Diabetes. Trends Mol Med. 2020 Aug;26(8):744-757.
- Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2480-2491.
- Young EP, Stitziel NO. Capitalizing on insights from human genetics to identify novel therapeutic targets for coronary artery disease. Annu Rev Med. 2019 Jan 27; 70:19-32.
- Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D, Musunuru K, Kathiresan S; PROMIS and Myocardial Infarction Genetics Consortium Investigators. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol. 2017 Apr 25;69(16):2054-2063.
- Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D; Brigham Genomic Medicine, Mecham RP, Frank NY, Stitziel NO. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8759-64
- Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, et al. Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. N Engl J Med. 2016 March 24th; 374:1134-1144
- View a complete list of Stitziel lab Publications